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KMID : 0613320060120010030
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Journal of the Korean Bone and Joint Tumor Soceity
2006 Volume.12 No. 1 p.30 ~ p.36
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Epithelioid Sarcoma
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Cho Wan-Hyeong
Jeon Dae-Geun
Park Jong-Hoon
Song Won-Seok
Lee Soo-Yong
Koh Jae-Soo
Ko Han-Sang
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Abstract
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Purpose: Epitheliod sarcoma is an obscure clinical entity. This study analyzes the correlation between the clinical course and the AJCC stage, presence of residual tumor and ezrin-expression.
Materials and Methods: Twenty-three cases of epithelioid sarcoma were eligible. All the cases had operation. Fifteen cases had systemic chemotherapy and 6 cases had adjuvant radiotherapy. Immumohistochemical analysis was done for 15 cases. Analyzed factors were initial stage, adjuvant treatment, local recurrence, residual tumor immumohistochemical results and surgical margin.
Results: The event free survival rate of 15 stage II, III cases was 47.4% at 129 months. The actual survival rate of 8 stage IV cases was 37.5% at 80 months. The presence of residual tumor tissue on re-excision specimen showed statistical significance on event free survival rate(P=0.03). Adjuvant therapy showed no impact on outcome. The stage IV and locally recurrent cases had a positive relation with Ezrin-positivity.
Conclusion: Residual tumor showed correlation in the outcome of epitheliod sarcoma. Chemotherapy and radiation therapy did not affect the outcome. Further case collection and analysis is needed for the significance between Ezrin expression and clinical behavior.
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KEYWORD
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Epithelioid Sarcoma, Survival
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